Immunogen
Synthesized peptide derived from human TRIM2 AA range: 162-212
Specificity
This antibody detects endogenous levels of TRIM2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic filaments. It plays a neuroprotective role and functions as an E3-ubiquitin ligase in proteasome-mediated degradation of target proteins. Mutations in this gene can cause early-onset axonal neuropathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014],
Function
domain:The interaction with myosin V is dependent upon its NHL repeats, which form a beta-propeller (NHL) domain containing six blades.,function:May contribute to the alteration of neural cellular mechanisms.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 filamin repeat.,similarity:Contains 1 RING-type zinc finger.,similarity:Contains 6 NHL repeats.,subunit:Interacts with myosin V.,
Gene Name
TRIM2 KIAA0517 RNF86
Human protein sequence Database
Q9C040
Mouse protein sequence database
Q9ESN6
Rat protein sequence database
D3ZQG6
Cellular localization
Cytoplasm .
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