Immunogen
Synthesized peptide derived from human LYRM4 AA range: 30-80
Specificity
This antibody detects endogenous levels of LYRM4 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is found in both mitochondria and the nucleus, where it binds cysteine desulfurase and helps free inorganic sulfur for Fe/S clusters. Disruption of this gene negatively impacts mitochondrial and cytosolic iron homeostasis. [provided by RefSeq, Sep 2016],
Function
function:May be involved in mitochondrial iron-sulfur protein biosynthesis.,miscellaneous:Reduction of LYRM4 levels by siRNA increases the total iron content, and reduces cytosolic and mitochondrial aconitase activities and NFS1 protein levels.,pathway:Cofactor biosynthesis; iron-sulfur cluster biosynthesis.,similarity:Belongs to the complex I LYR family.,subunit:Interacts with FXN. Interaction is increased by nickel. Interaction is inhibited by calcium, magnesium, manganese, copper, cobalt, zinc, and iron. Forms a complex with the cytosolic/nuclear form of NFS1. The complex increased the stability of NFS1.,tissue specificity:Reduced mRNA levels in Friedreich ataxia (FA) patients.,
Gene Name
LYRM4 C6orf149 ISD11 CGI-203
Human protein sequence Database
Q9HD34
Mouse protein sequence database
Q8K215
Rat protein sequence database
Cellular localization
Mitochondrion. Nucleus.
Tissue expression
Reduced mRNA levels in Friedreich ataxia patients.
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