Immunogen
Synthesized peptide derived from human GRAM4 AA range: 304-354
Specificity
This antibody detects endogenous levels of GRAM4 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
GRAMD4 is a mitochondrial effector of E2F1 (MIM 189971)-induced apoptosis (Stanelle et al., 2005 [PubMed 15565177]).[supplied by OMIM, Jan 2011],
Function
domain:The leucine-zipper is involved in homodimerization.,function:Plays a role as a mediator of e2f1-induced apoptosis in the absence of tp53/p53.,function:Protects T-cells from IL2 deprivation-induced apoptosis through the inhibition of FOXO3A transcriptional activity that leads to the down-regulation of the pro-apoptotic factor BCL2L11. In macrophages, plays a role in the anti-inflammatory and immunosuppressive effects of glucocorticoids and IL10. In T-cells, inhibits anti-CD3-induced NFKB1 nuclear translocation. In vitro, suppresses AP1 and NFKB1 DNA-binding activities.,induction:By glucocorticoids in lymphoid cells and upon IL4, IL10, IL13 or glucocorticoid treatment in monocyte/macrophage cells. Transiently induced by IL2 deprivation in T-cells.,induction:Up-regulated in the mitochondria by E2F1 after addition of 4-hydroxytamoxifen (at protein level).,similarity:Belongs to the TSC
Gene Name
GRAMD4 DIP KIAA0767
Human protein sequence Database
Q6IC98
Mouse protein sequence database
Q8CB44
Rat protein sequence database
Cellular localization
Mitochondrion membrane ; Multi-pass membrane protein . Endoplasmic reticulum membrane ; Multi-pass membrane protein . Colocalizes with COX4I1. .
Tissue expression
Expressed in lung and in primary lung squamous cell carcinoma (LSCC).
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