Immunogen
Synthesized peptide derived from human MTNB AA range: 133-183
Specificity
This antibody detects endogenous levels of MTNB at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008],
Function
cofactor:Binds 1 zinc ion per subunit .,function:Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c-dependent and APAF1-mediated cell death.,similarity:Belongs to the aldolase class II family. APIP subfamily.,subunit:Interacts with APAF1.,tissue specificity:Ubiquitously expressed with high expression in skeletal muscle, heart and kidney.,
Fields
>>Cysteine and methionine metabolism;>>Metabolic pathways
Human protein sequence Database
Q96GX9
Mouse protein sequence database
Q9WVQ5
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Isoform 1 is ubiquitously expressed. Isoform 2 is expressed at lower levels and detected in heart, brain, pancreas, liver, placenta, skeletal muscle and kidney.
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