Immunogen
Synthesized peptide derived from human SG11A AA range: 56-106
Specificity
This antibody detects endogenous levels of SG11A at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008],
Function
polymorphism:The microheterogeneity probably represents an allelic variant.,sequence caution:Translated as Glu.,similarity:Belongs to the SPAG11 family.,tissue specificity:Specifically expressed in caput and proximal corpus of epididymis. Present in the epididymal epithelium and on the sperm surface, with a subacrosomal equatorial distribution on the sperm head.,
Gene Name
SPAG11A EP2 HE2
Human protein sequence Database
Q6PDA7
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted .
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