Immunogen
Synthesized peptide derived from human DOC2A AA range: 22-72
Specificity
This antibody detects endogenous levels of DOC2A at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
There are at least two protein isoforms of the Double C2 protein, namely alpha (DOC2A) and beta (DOC2B), which contain two C2-like domains. DOC2A and DOC2B are encoded by different genes; these genes are at times confused with the unrelated DAB2 gene which was initially named DOC-2. DOC2A is mainly expressed in brain and is suggested to be involved in Ca(2+)-dependent neurotransmitter release. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013],
Function
domain:C2 domain 1 is involved in binding calcium and phospholipids.,function:May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in dynein-dependent intracellular vesicle transport. In vitro, binds calcium and phospholipids.,similarity:Contains 2 C2 domains.,subcellular location:Colocalizes to synaptic vesicles.,subunit:Interacts through its N-terminus with UNC13A. Interacts with cytoplasmic dynein light chain TCTEL1/TCTEX1.,tissue specificity:Predominantly expressed in brain. Also expressed in testis.,
Human protein sequence Database
Q14183
Mouse protein sequence database
Q7TNF0
Rat protein sequence database
P70611
Cellular localization
Lysosome . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Peripheral membrane protein . Cell junction, synapse, synaptosome.
Tissue expression
Predominantly expressed in brain. Also expressed in testis.
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