Immunogen
Synthesized peptide derived from human NSD3 AA range: 1373-1423
Specificity
This antibody detects endogenous levels of NSD3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is related to the Wolf-Hirschhorn syndrome candidate-1 gene and encodes a protein with PWWP (proline-tryptophan-tryptophan-proline) domains. This protein methylates histone H3 at lysine residues 4 and 27, which represses gene transcription. Two alternatively spliced variants have been described. [provided by RefSeq, May 2015],
Function
catalytic activity:S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N(6)-methyl-L-lysine.,disease:A chromosomal aberration involving WHSC1L1 is found in childhood acute myeloid leukemia. Translocation t(8;11)(p11.2;p15) with NUP98.,disease:Defects in WHSC1L1 may be involved in non small cell lung carcinomas (NSCLC). Amplified or overexpressed in NSCLC.,function:Histone methyltransferase. Preferentially methylates 'Lys-4' and 'Lys-27' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the histone-lysine methyltransferase family. SET2 subfamily.,similarity:Contains 1 AWS domain.,similarity:Contains 1 post-SET domain.,similarity:Contains 1 SET domain.,similari
Gene Name
WHSC1L1 NSD3 DC28
Fields
>>Lysine degradation;>>Metabolic pathways
Human protein sequence Database
Q9BZ95
Mouse protein sequence database
Q6P2L6
Rat protein sequence database
Cellular localization
Nucleus . Chromosome .
Tissue expression
Highly expressed in brain, heart and skeletal muscle. Expressed at lower level in liver and lung.
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