Immunogen
Synthesized peptide derived from human KCTD3 AA range: 360-410
Specificity
This antibody detects endogenous levels of KCTD3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the potassium channel tetramerization-domain containing (KCTD) protein family. Members of this protein family regulate the biophysical characteristics of ion channels. In mouse, this protein interacts with hyperpolarization-activated cyclic nucleotide-gated channel complex 3 and enhances its cell surface expression and current density. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016],
Function
miscellaneous:Reacts with sera from 5-25 per cent of cancer patients but not with sera from normal donors. Seventy per cent of renal cancer patients have antibodies against one or a panel of these antigens.,sequence caution:Contaminating sequence. Potential poly-A sequence.,similarity:Belongs to the KCTD3 family.,similarity:Contains 1 BTB (POZ) domain.,similarity:Contains 5 WD repeats.,tissue specificity:Broadly expressed in normal tissues.,
Human protein sequence Database
Q9Y597
Mouse protein sequence database
Q8BFX3
Rat protein sequence database
Cellular localization
Cell membrane .
Tissue expression
Broadly expressed in normal tissues.
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