Immunogen
Synthesized peptide derived from human PRCC AA range: 74-124
Specificity
This antibody detects endogenous levels of PRCC at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that may play a role in pre-mRNA splicing. Chromosomal translocations (X;1)(p11;q21) that result in fusion of this gene to TFE3 (GeneID 7030) have been associated with papillary renal cell carcinoma. A PRCC-TFE3 fusion protein is expressed in affected carcinomas and is likely associated with altered gene transactivation. This fusion protein has also been associated with disruption of the cell cycle.[provided by RefSeq, Aug 2010],
Function
caution:The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.,disease:A chromosomal aberration involving PRCC may be a cause of papillary renal cell carcinoma (PRCC) [MIM:605074]. Translocation t(X;1)(p11.2;q21.2) with TFE3.,tissue specificity:Ubiquitous in fetal and adult tissues.,
Fields
>>Transcriptional misregulation in cancer;>>Renal cell carcinoma
Human protein sequence Database
Q92733
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Ubiquitous in fetal and adult tissues.
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