Immunogen
Synthesized peptide derived from human EST5A AA range: 278-328
Specificity
This antibody detects endogenous levels of EST5A at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
Function
catalytic activity:A carboxylic ester + H(2)O = an alcohol + a carboxylate.,caution:Was named CES5 by Ref.1.,function:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.,PTM:N-glycosylated.,similarity:Belongs to the type-B carboxylesterase/lipase family.,
Human protein sequence Database
Q6NT32
Mouse protein sequence database
Q6AW46
Rat protein sequence database
Q5GRG2
Cellular localization
Secreted .
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