Immunogen
Synthesized peptide derived from human SETBP AA range: 990-1040
Specificity
This antibody detects endogenous levels of SETBP at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein which contains a several motifs including a ski homology region and a SET-binding region in addition to three nuclear localization signals. The encoded protein has been shown to bind the SET nuclear oncogene which is involved in DNA replication. Mutations in this gene are associated with Schinzel-Giedion midface retraction syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011],
Function
similarity:Contains 3 A.T hook DNA-binding domains.,subunit:Interacts with SET.,tissue specificity:Expressed in numerous tissues.,
Gene Name
SETBP1 KIAA0437
Human protein sequence Database
Q9Y6X0
Mouse protein sequence database
Q9Z180
Rat protein sequence database
Cellular localization
Nucleus .
Tissue expression
Expressed in numerous tissues. Expressed at low levels in myeloid and monocytic cells as well as in CD34+ cells; expression levels are higher in myeloid malignancies.
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