Immunogen
Synthesized peptide derived from human SO4C1 AA range: 77-127
Specificity
This antibody detects endogenous levels of SO4C1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
SLCO4C1 belongs to the organic anion transporter (OATP) family. OATPs are involved in the membrane transport of bile acids, conjugated steroids, thyroid hormone, eicosanoids, peptides, and numerous drugs in many tissues (Mikkaichi et al., 2004 [PubMed 14993604]).[supplied by OMIM, Mar 2008],
Function
function:Organic anion transporter, capable of transporting pharmacological substances such as digoxin, ouabain, thyroxine, methotrexate and cAMP. May participate in the regulation of membrane transport of ouabain. Involved in the uptake of the dipeptidyl peptidase-4 inhibitor sitagliptin and hence may play a role in its transport into and out of renal proximal tubule cells. May be involved in the first step of the transport pathway of digoxin and various compounds into the urine in the kidney. May be involved in sperm maturation by enabling directed movement of organic anions and compounds within or between cells. This ion-transporting process is important to maintain the strict epididymal homeostasis necessary for sperm maturation. May have a role in secretory functions since seminal vesicle epithelial cells are assumed to secrete proteins involved in decapacitation by modifying surfac
Gene Name
SLCO4C1 OATP4C1 OATPX SLC21A20
Human protein sequence Database
Q6ZQN7
Mouse protein sequence database
Q8BGD4
Rat protein sequence database
Q71MB6
Cellular localization
Basolateral cell membrane ; Multi-pass membrane protein . Detected at the basolateral membrane of the proximal tubule cell in the kidney. .
Tissue expression
Predominantly expressed in kidney but also weakly expressed in both fetal liver and kidney.
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