Immunogen
Synthesized peptide derived from human SHRM3 AA range: 777-827
Specificity
This antibody detects endogenous levels of SHRM3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a PDZ-domain-containing protein that belongs to a family of Shroom-related proteins. This protein may be involved in regulating cell shape in certain tissues. A similar protein in mice is required for proper neurulation. [provided by RefSeq, Jan 2011],
Function
domain:The ASD1 domain mediates F-actin binding.,domain:The ASD2 domain is required for apical constriction induction.,function:Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers. Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays.,similarity:Belongs to the shroom family.,similarity:Contains 1 ASD1 domain.,similarity:Contains 1 ASD2 domain.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Colocalizes with F-actin in stress fibers and adherens junctions.,subunit:Interacts with F-actin.,
Gene Name
SHROOM3 KIAA1481 SHRML MSTP013
Human protein sequence Database
Q8TF72
Mouse protein sequence database
Q9QXN0
Rat protein sequence database
Cellular localization
Cell junction, adherens junction . Cytoplasm, cytoskeleton . Apical cell membrane ; Peripheral membrane protein . Colocalizes with F-actin in stress fibers and adherens junctions. .
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