Immunogen
Synthesized peptide derived from human FCERG AA range: 31-81
Specificity
This antibody detects endogenous levels of FCERG at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The high affinity IgE receptor is a key molecule involved in allergic reactions. It is a tetramer composed of 1 alpha, 1 beta, and 2 gamma chains. The gamma chains are also subunits of other Fc receptors. [provided by RefSeq, Jul 2008],
Function
function:Associates with a variety of FcR alpha chains to form a functional signaling complex. Regulates several aspects of the immune response. The gamma subunit has a critical role in allowing the IgE Fc receptor to reach the cell surface.,similarity:Belongs to the CD3Z/FCER1G family.,similarity:Contains 1 ITAM domain.,subunit:IgE Fc receptor is a tetramer of an alpha chain, a beta chain, and two disulfide linked gamma chains. The gamma chain from Fc-epsilon-Ri are also subunits of other Fc receptors like FCGR1A.,
Fields
>>Sphingolipid signaling pathway;>>Phospholipase D signaling pathway;>>Platelet activation;>>C-type lectin receptor signaling pathway;>>Natural killer cell mediated cytotoxicity;>>Fc epsilon RI signaling pathway;>>Tuberculosis;>>Asthma
Human protein sequence Database
P30273
Mouse protein sequence database
P20491
Rat protein sequence database
P20411
Cellular localization
Cell membrane ; Single-pass type I membrane protein .
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