Molecular weight (DA)
64kD
Immunogen
Synthesized peptide derived from human STIP1/HOP AA range: 250-300
Specificity
This antibody detects endogenous levels of STIP1/HOP at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.82% sodium azide.
Dilution rate
IHC-p1:50-200 ,WB 1:1000-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009],
Function
domain:The TPR 1 repeat interacts with the C-terminal of HSC70. The TPR 4, 5 and 6 repeats (also called TPR2A domain) and TPR 7, 8 and 9 repeats (also called TPR2B domain) interact with HSP90.,function:Mediates the association of the molecular chaperones HSC70 and HSP90 (HSPCA and HSPCB).,similarity:Contains 2 STI1 domains.,similarity:Contains 9 TPR repeats.,subunit:Forms a complex with HSC70 and HSPCA/HSP-86 and HSPCB/HSP-84. Interacts with PACRG.,
Other name
Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)
Human protein sequence Database
P31948
Mouse protein sequence database
Q60864
Rat protein sequence database
O35814
Cellular localization
Cytoplasm . Nucleus . Dynein axonemal particle .
Tissue expression
B-cell lymphoma,Brain,Cajal-Retzius cell,Epithelium,Fetal brain cortex,Kera
Contract Us
Follow Us
Location： 
Specification
成功添加到购物车