Molecular weight (DA)
280kD
Immunogen
Synthesized peptide derived from human MAP2 (Phospho-Thr1616)
Specificity
This antibody detects endogenous phospho levels of MAP2 (Phospho-Thr1616) at Human:T1616, Mouse:T1620, Rat:T1622
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that belongs to the microtubule-associated protein family. The proteins of this family are thought to be involved in microtubule assembly, which is an essential step in neurogenesis. The products of similar genes in rat and mouse are neuron-specific cytoskeletal proteins that are enriched in dentrites, implicating a role in determining and stabilizing dentritic shape during neuron development. A number of alternatively spliced variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2010],
Function
alternative products:Additional isoforms seem to exist,function:The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules.,PTM:MAP2A/c is phosphorylated. Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 3 Tau/MAP repeats.,similarity:Contains 4 Tau/MAP repeats.,
Protein name
MAP2 (Phospho-Thr1616)
Other name
Microtubule-associated protein 2 (MAP-2)
Human protein sequence Database
P11137
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm, cytoskeleton . Cell projection, dendrite .
Tissue expression
Brain,Brain cortex,Epithelium,Pancreas,Testis,
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