Immunogen
Synthesized peptide derived from human XRCC1 (Phospho-Thr284)
Specificity
This antibody detects endogenous levels of XRCC1 (Phospho-Thr284) at Human, Mouse,Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, and 0.171% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008],
Function
function:Corrects defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents.,polymorphism:Carriers of the polymorphic Gln-399 allele may be at greater risk for tobacco- and age-related DNA damage.,PTM:Phosphorylation of Ser-371 causes dimer dissociation. Phosphorylation by CK2 promotes interaction with APTX and APLF.,PTM:Sumoylated.,similarity:Contains 2 BRCT domains.,subcellular location:Accumulates at sites of DNA damage.,subunit:Homodimer. Interacts with polynucleotide kinase (PNK), DNA polymerase-beta (POLB) and DNA ligase III (LIG3). Interacts with APTX and APLF.,
Protein name
XRCC1 (Phospho-Thr284)
Other name
DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)
Fields
>>Base excision repair
Human protein sequence Database
P18887
Mouse protein sequence database
Q60596
Rat protein sequence database
Q9ESZ0
Cellular localization
Nucleus . Moves from the nucleoli to the global nuclear chromatin upon DNA damage. .
Tissue expression
Expressed in fibroblasts, retinal pigmented epithelial cells and lymphoblastoid cells (at protein level).
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