Molecular weight (DA)
40kD
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human SSTR2. AA range:220-270
Specificity
SSTR2 Polyclonal Antibody detects endogenous levels of somatostatin receptor 2
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
Somatostatin acts at many sites to inhibit the release of many hormones and other secretory proteins. The biologic effects of somatostatin are probably mediated by a family of G protein-coupled receptors that are expressed in a tissue-specific manner. SSTR2 is a member of the superfamily of receptors having seven transmembrane segments and is expressed in highest levels in cerebrum and kidney. [provided by RefSeq, Jul 2008],
Function
function:Receptor for somatostatins-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. In RIN-5F cells, this receptor inhibits calcium entry by suppressing voltage dependent calcium-channels.,similarity:Belongs to the G-protein coupled receptor 1 family.,subunit:The C-terminus interacts with SHANK1 PDZ domain.,tissue specificity:Cerebrum and kidney. In lesser amounts in jejunum, colon and liver.,
Protein name
somatostatin receptor 2
Other name
Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SRIF-1)
Fields
>>cAMP signaling pathway;>>Neuroactive ligand-receptor interaction;>>Growth hormone synthesis, secretion and action;>>Gastric acid secretion
Human protein sequence Database
P30874
Mouse protein sequence database
P30875
Rat protein sequence database
P30680
Cellular localization
Cell membrane; Multi-pass membrane protein. Cytoplasm. Located mainly at the cell surface under basal conditions. Agonist stimulation results in internalization to the cytoplasm.
Tissue expression
Expressed in both pancreatic alpha- and beta-cells (at protein level). Expressed at higher levels in the pancreas than other somatostatin receptors. Also expressed in the cerebrum and kidney and, in lesser amounts, in the jejunum, colon and liver. In the developing nervous system, expressed in the cortex where it is located in the preplate at early stages and is enriched in the outer part of the germinal zone at later stages. In the cerebellum, expressed in the deep part of the external granular layer at gestational week 19. This pattern persists until birth but disappears at adulthood.
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