Molecular weight (DA)
170kD
Immunogen
Synthetic peptide from human protein at AA range: 660-700
Specificity
The antibody detects endogenous IRS2 protein
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000, ELISA 1:10000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes the insulin receptor substrate 2, a cytoplasmic signaling molecule that mediates effects of insulin, insulin-like growth factor 1, and other cytokines by acting as a molecular adaptor between diverse receptor tyrosine kinases and downstream effectors. The product of this gene is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation, as well as by an interleukin 4 receptor-associated kinase in response to IL4 treatment. [provided by RefSeq, Jul 2008],
Function
function:May mediate the control of various cellular processes by insulin.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Contains 1 IRS-type PTB domain.,similarity:Contains 1 PH domain.,
Protein name
insulin receptor substrate 2
Fields
>>cGMP-PKG signaling pathway;>>FoxO signaling pathway;>>Autophagy - animal;>>AMPK signaling pathway;>>Longevity regulating pathway;>>Longevity regulating pathway - multiple species;>>Insulin signaling pathway;>>Adipocytokine signaling pathway;>>Regulation of lipolysis in adipocytes;>>Type II diabetes mellitus;>>Insulin resistance;>>Non-alcoholic fatty liver disease;>>Growth hormone synthesis, secretion and action;>>Alzheimer disease;>>MicroRNAs in cancer
Human protein sequence Database
Q9Y4H2
Mouse protein sequence database
P81122
Rat protein sequence database
Cellular localization
Cytoplasm, cytosol .
Tissue expression
Blood,Epithelium,Platelet,
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