Immunogen
Synthetic peptide from human protein at AA range: 141-190
Specificity
The antibody detects endogenous IL-17D
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, ELISA 1:10000-20000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded by this gene is a cytokine that shares the sequence similarity with IL17. The treatment of endothelial cells with this cytokine has been shown to stimulate the production of other cytokines including IL6, IL8 and CSF2/ GM-CSF. The increased expression of IL8 induced by this cytokine was found to be NF-kappa B-dependent. [provided by RefSeq, Jul 2008],
Function
function:Induces expression of IL-6, IL-8, and GM-CSF from endothelial cells.,online information:Interleukin-17 entry,similarity:Belongs to the IL-17 family.,tissue specificity:Expressed preferentially in adipose, skeletal muscle and CNS.,
Gene Name
IL17D IL27 UNQ3096/PRO21175
Protein name
Interleukin-17D (IL-17D) (Interleukin-27) (IL-27)
Other name
Interleukin-17D (IL-17D;Interleukin-27;IL-27)
Fields
>>Cytokine-cytokine receptor interaction;>>C-type lectin receptor signaling pathway;>>JAK-STAT signaling pathway;>>IL-17 signaling pathway
Human protein sequence Database
Q8TAD2
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted.
Tissue expression
Expressed preferentially in adipose, skeletal muscle and CNS.
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