Molecular weight (DA)
125kD
Immunogen
Synthesized peptide derived from human DIAP2
Specificity
This antibody detects endogenous levels of human DIAP2
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The product of this gene belongs to the diaphanous subfamily of the formin homology family of proteins. This gene may play a role in the development and normal function of the ovaries. Defects in this gene have been linked to premature ovarian failure 2. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008],
Function
developmental stage:Expressed from E16 in ovary and testis and during P6-P16 during differentiation of ovarian follicles.,disease:Defects in DIAPH2 are a cause of premature ovarian failure 2 (POF2) [MIM:300511]. Premature ovarian failure (POF) is a defect of ovarian development and is characterized by hypoestrogenism, primary or secondary amenorrhea, with elevated levels of serum gonadotropins, or by early menopause. POF is defined as the cessation of ovarian function under the age of 40 years. The disorder has been attributed to various causes, including rearrangements of a large "critical region" in the long arm of the X chromosome.,domain:DRFs are regulated by intramolecular GBD-DAD binding where Rho-GTP activates the DRFs by disrupting the GBD-DAD interaction.,function:Could be involved in oogenesis. Involved in the regulation of endosome dynamics. Implicated in a novel signal transd
Other name
Protein diaphanous homolog 2 (Diaphanous-related formin-2;DRF2)
Fields
>>Regulation of actin cytoskeleton
Human protein sequence Database
O60879
Mouse protein sequence database
Rat protein sequence database
Cellular localization
[Isoform 3]: Cytoplasm, cytosol. Early endosome. Isoform 3 is cytosolic but when coexpressed with RHOD, the 2 proteins colocalize to early endosomes.
Tissue expression
Expressed in testis, ovary, small intestine, prostate, lung, liver, kidney and leukocytes.
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