Molecular weight (DA)
27kD
Immunogen
Synthesized peptide derived from human TRY2
Specificity
This antibody detects endogenous levels of human TRY2
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene belongs to the trypsin family of serine proteases and encodes anionic trypsinogen. It is part of a cluster of trypsinogen genes that are located within the T cell receptor beta locus. Enzymes of this family cleave peptide bonds that follow lysine or arginine residues. This protein is found at high levels in pancreatic juice and its upregulation is a characteristic feature of pancreatitis. This protein has also been found to activate pro-urokinase in ovarian tumors, suggesting a function in tumor invasion. In addition, this enzyme is able to cleave across the type II collagen triple helix in rheumatoid arthritis synovitis tissue, potentially participating in the degradation of type II collagen-rich cartilage matrix. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2015],
Function
catalytic activity:Preferential cleavage: Arg-|-Xaa, Lys-|-Xaa.,cofactor:Binds 1 calcium ion per subunit.,PTM:Sulfated on tyrosine.,similarity:Belongs to the peptidase S1 family.,similarity:Contains 1 peptidase S1 domain.,
Gene Name
PRSS2 TRY2 TRYP2
Other name
Trypsin-2 (EC 3.4.21.4;Anionic trypsinogen;Serine protease 2;Trypsin II)
Fields
>>Neuroactive ligand-receptor interaction;>>Pancreatic secretion;>>Protein digestion and absorption;>>Influenza A
Human protein sequence Database
P07478
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Secreted, extracellular space.
Tissue expression
Expressed in Paneth cells, at the base of small intestinal crypts.
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