Molecular weight (DA)
38kD
Immunogen
Synthesized peptide derived from human GRASP
Specificity
This antibody detects endogenous levels of human GRASP
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1:50-200, WB 1:500-2000. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein that functions as a molecular scaffold, linking receptors, including group 1 metabotropic glutamate receptors, to neuronal proteins. The encoded protein contains conserved domains, including a leucine zipper sequence, PDZ domain and a C-terminal PDZ-binding motif. Alternately spliced transcript variants have been observed for this gene.[provided by RefSeq, Dec 2012],
Function
function:Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.,similarity:Contains 1 PDZ (DHR) domain.,subcellular location:Localized at postsynaptic membranes.,subunit:Heteromer. Composed of GRASP, PSCD2 and at least one GRM1. Also interacts with PSCD3, GRM2, GRM3 and GRM5.,
Other name
General receptor for phosphoinositides 1-associated scaffold protein (GRP1-associated scaffold protein)
Human protein sequence Database
Q7Z6J2
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm, perinuclear region . Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell junction, synapse, postsynaptic cell membrane .
Tissue expression
Ovary,Skin,
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