Immunogen
Synthesized peptide derived from human SPNXA AA range: 42-92
Specificity
This antibody detects endogenous levels of SPNXA at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Temporally regulated transcription and translation of several testis-specific genes is required to initiate the series of molecular and morphological changes in the male germ cell lineage necessary for the formation of mature spermatozoa. This gene is a member of the SPANX family of cancer/testis-associated genes, which are located in a cluster on chromosome X. The SPANX genes encode differentially expressed testis-specific proteins that localize to various subcellular compartments. This particular gene maps to chromosome X in a head-to-head orientation with SPANX family member A2, which appears to be a duplication of the A1 locus. The protein encoded by this gene targets to the nucleus where it associates with nuclear vacuoles and the redundant nuclear envelope. Based on its association with these poorly characterized regions of the sperm nucleus, this protein provides a biochemical marker to study unique structures in spermatazoa while attempting to further define its role in spermatogenesis. [provided by RefSeq, Jul 2008],
Function
developmental stage:Detected in round and elongating spermatids.,similarity:Belongs to the SPAN-X family.,subcellular location:Associated with nuclear craters.,tissue specificity:Detected in testis and sperm.,
Gene Name
SPANXA1 SPANXA; SPANXA2
Human protein sequence Database
Q9NS26
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm . Nucleus . Associated with nuclear craters.
Tissue expression
Detected in testis and sperm.
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