Immunogen
Synthesized peptide derived from human DEGS2 AA range: 92-142
Specificity
This antibody detects endogenous levels of DEGS2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a bifunctional enzyme that is involved in the biosynthesis of phytosphingolipids in human skin and in other phytosphingolipid-containing tissues. This enzyme can act as a sphingolipid delta(4)-desaturase, and also as a sphingolipid C4-hydroxylase. [provided by RefSeq, Oct 2008],
Function
function:Bifunctional enzyme which acts as both a sphingolipid delta(4)-desaturase and a sphingolipid C4-hydroxylase.,induction:Up-regulated during keratinocyte differentiation. Not expressed at day 0 or day 3 after differentiation, detected on day 6 and increases by day 9.,pathway:Membrane lipid metabolism; sphingolipid biosynthesis.,similarity:Belongs to the fatty acid desaturase family. DEGS subfamily.,tissue specificity:Highly expressed in skin, intestine and kidney.,
Fields
>>Sphingolipid metabolism;>>Metabolic pathways;>>Sphingolipid signaling pathway
Human protein sequence Database
Q6QHC5
Mouse protein sequence database
Q8R2F2
Rat protein sequence database
Q564G3
Cellular localization
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
Tissue expression
Highly expressed in skin, intestine and kidney.
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