Immunogen
Synthesized peptide derived from human SHOX2 AA range: 37-87
Specificity
This antibody detects endogenous levels of SHOX2 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300,FCM 1:100-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene is a member of the homeobox family of genes that encode proteins containing a 60-amino acid residue motif that represents a DNA binding domain. Homeobox genes have been characterized extensively as transcriptional regulators involved in pattern formation in both invertebrate and vertebrate species. Several human genetic disorders are caused by aberrations in human homeobox genes. This locus represents a pseudoautosomal homeobox gene that is thought to be responsible for idiopathic short stature, and it is implicated in the short stature phenotype of Turner syndrome patients. This gene is considered to be a candidate gene for Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2009],
Function
developmental stage:Expressed during cranofacial development as well as in heart.,function:May be a growth regulator and have a role in specifying neural systems involved in processing somatosensory information, as well as in face and body structure formation.,similarity:Belongs to the paired homeobox family. Bicoid subfamily.,similarity:Contains 1 homeobox DNA-binding domain.,similarity:Contains 1 OAR domain.,tissue specificity:Expressed in heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas and placenta.,
Gene Name
SHOX2 OG12X SHOT
Human protein sequence Database
O60902
Mouse protein sequence database
P70390
Rat protein sequence database
O35750
Cellular localization
Nucleus.
Tissue expression
Expressed in heart, skeletal muscle, liver, lung, bone marrow fibroblast, pancreas and placenta.
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