Immunogen
Synthesized peptide derived from human BEAN1 AA range: 146-196
Specificity
This antibody detects endogenous levels of BEAN1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
wb 1:1000 IP:1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is one of several proteins that interact with NEDD4, a member of a family of ubiquitin-protein ligases. These proteins have PY motifs in common that bind to the WW domains of NEDD4. NEDD4 is developmentally regulated, and is highly expressed in embryonic tissues. Mutations in this gene (i.e., intronic insertions of >100 copies of pentanucleotide repeats including a (TGGAA)n sequence) are associated with spinocerebellar ataxia type 31. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010],
Function
subunit:Interacts with NEDD4.,
Fields
>>Spinocerebellar ataxia
Human protein sequence Database
Q3B7T3
Mouse protein sequence database
Q9EQG5
Rat protein sequence database
Cellular localization
Membrane ; Single-pass membrane protein .
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