Immunogen
Synthesized peptide derived from human LRC3B AA range: 115-165
Specificity
This antibody detects endogenous levels of LRC3B at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015],
Function
similarity:Belongs to the LRRC3 family.,similarity:Contains 3 LRR (leucine-rich) repeats.,
Gene Name
LRRC3B LRP15 UNQ195/PRO221
Human protein sequence Database
Q96PB8
Mouse protein sequence database
Q8VCH9
Rat protein sequence database
Cellular localization
Membrane ; Single-pass membrane protein .