Immunogen
Synthesized peptide derived from human GCM1 AA range: 298-348
Specificity
This antibody detects endogenous levels of GCM1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a DNA-binding protein with a gcm-motif (glial cell missing motif). The encoded protein is a homolog of the Drosophila glial cells missing gene (gcm). This protein binds to the GCM-motif (A/G)CCCGCAT, a novel sequence among known targets of DNA-binding proteins. The N-terminal DNA-binding domain confers the unique DNA-binding activity of this protein. [provided by RefSeq, Jul 2008],
Function
function:Transcription factor that is necessary for placental development. Binds to the trophoblast-specific element 2 (TSE2) of the aromatase gene enhancer.,similarity:Contains 1 GCM DNA-binding domain.,tissue specificity:Placenta specific.,
Fields
>>Parathyroid hormone synthesis, secretion and action
Human protein sequence Database
Q9NP62
Mouse protein sequence database
P70348
Rat protein sequence database
Q9Z288
Cellular localization
Nucleus .
Tissue expression
Highly expressed in the placenta (PubMed:10542267). Expressed in trophoblast cells of the villi (PubMed:27917469).
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