Immunogen
Synthesized peptide derived from human RT4I1 AA range: 282-332
Specificity
This antibody detects endogenous levels of RT4I1 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, mental retardation, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],
Function
function:Appears to be a potent inhibitor of regeneration following spinal cord injury.,similarity:Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.,subunit:Interacts with RTN4, UQCRC1 and UQCRC2.,tissue specificity:Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.,
Human protein sequence Database
Q8WWV3
Mouse protein sequence database
Q924D0
Rat protein sequence database
Cellular localization
Mitochondrion outer membrane . Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria. .
Tissue expression
Widely expressed in mitochondria-enriched tissues. Found in heart, muscle, kidney, liver, brain and placenta.
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