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CRNL1 rabbit pAb

Refer to | for labeled antibodies

Specification

BYab-11440

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Host
Reactiveness
Use
Molecular weight (DA)
Immunogen
Synthesized peptide derived from human CRNL1 AA range: 710-760
Specificity
This antibody detects endogenous levels of CRNL1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Background
The crooked neck (crn) gene of Drosophila is essential for embryogenesis and is thought to be involved in cell cycle progression and pre-mRNA splicing. A protein encoded by this human locus has been found to localize to pre-mRNA splicing complexes in the nucleus and is necessary for pre-mRNA splicing. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2013],
Function
function:Involved in pre-mRNA splicing process.,similarity:Belongs to the crooked-neck family.,similarity:Contains 17 HAT repeats.,subcellular location:Colocalizes with core spliceosomal snRNP proteins. Also diffusely expressed in cytoplasm.,subunit:Identified in the spliceosome C complex, at least composed of AQR, C19orf29, CDC40, CDC5L, CRNKL1, DDX23, DDX41, DDX48, DDX5, DGCR14, DHX35, DHX38, DHX8, EFTUD2, FRG1, GPATC1, HNRPA1, HNRPA2B1, HNRPA3, HNRPC, HNRPF, HNRPH1, HNRPK, HNRPM, HNRPR, HNRPU, KIAA1160, KIAA1604, LSM2, LSM3, MAGOH, MORG1, PABPC1, PLRG1, PNN, PPIE, PPIL1, PPIL3, PPWD1, PRPF19, PRPF4B, PRPF6, PRPF8, RALY, RBM22, RBM8A, RBMX, SART1, SF3A1, SF3A2, SF3A3, SF3B1, SF3B2, SF3B3, SFRS1, SKIV2L2, SNRNP200, SNRNP40, SNRPA1, SNRPB, SNRPB2, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, SNW1, SRRM1, SRRM2, SYF2, SYNCRIP, TFIP11, THOC4, U2AF1, XAB2 and ZCCHC8. Present in a spliceosom
Gene Name
CRNKL1 CRN CGI-201 MSTP021
Protein name
CRNL1
Abbreviation
CRNL1
Other name
Fields
>>Spliceosome
Human gene ID
51340
Human protein sequence Database
Q9BZJ0
Mouse gene ID
66877
Mouse protein sequence database
P63154
Rat gene ID
100910202
Rat protein sequence database
P63155
Cellular localization
Nucleus . Nucleus speckle . Colocalizes with core spliceosomal snRNP proteins (PubMed:12084575). .
Tissue expression
Widely expressed (PubMed:11342225). Highly expressed in testis (PubMed:12084575). Not detected in brain and lung (PubMed:12084575).
Storage
-20°C/1 year

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CRNL1 rabbit pAb

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