Immunogen
Synthesized peptide derived from human LX15B AA range: 576-626
Specificity
This antibody detects endogenous levels of LX15B at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008],
Function
catalytic activity:Arachidonate + O(2) = (5Z,8Z,11Z,13E)-(15S)-15-hydroperoxyicosa-5,8,11,13-tetraenoate.,cofactor:Binds 1 iron ion per subunit.,function:Converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while linoleic acid is less well metabolized.,pathway:Lipid metabolism; leukotriene D4 biosynthesis.,similarity:Belongs to the lipoxygenase family.,similarity:Contains 1 lipoxygenase domain.,similarity:Contains 1 PLAT domain.,tissue specificity:Expressed in hair, prostate, lung and cornea.,
Fields
>>Arachidonic acid metabolism;>>Metabolic pathways;>>Serotonergic synapse
Human protein sequence Database
O15296
Mouse protein sequence database
O35936
Rat protein sequence database
Q8K4F2
Cellular localization
[Isoform A]: Nucleus . Other isoforms are excluded from the nucleus. .; Cytoplasm, cytosol . Cell membrane . Cytoplasm, cytoskeleton . Membrane ; Peripheral membrane protein . Cell junction, adherens junction . Cell junction, focal adhesion . Predominantly cytosolic; becomes enriched at membranes upon calcium binding. .
Tissue expression
Expressed in hair, prostate, lung, ovary, lymph node, spinal cord and cornea.
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