Immunogen
Synthesized peptide derived from human CDC26 AA range: 21-71
Specificity
This antibody detects endogenous levels of CDC26 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
IHC-p 1：50-200. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is highly similar to Saccharomyces cerevisiae Cdc26, a component of cell cycle anaphase-promoting complex (APC). APC is composed of a group of highly conserved proteins and functions as a cell cycle-regulated ubiquitin-protein ligase. APC thus is responsible for the cell cycle regulated proteolysis of various proteins. [provided by RefSeq, Jul 2008],
Function
function:Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase that controls progression through mitosis and the G1 phase of the cell cycle. May recruit the E2 ubiquitin-conjugating enzymes to the complex.,pathway:Protein modification; protein ubiquitination.,PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.,similarity:Belongs to the CDC26 family.,subunit:The APC/C is composed of at least 11 subunits.,
Gene Name
CDC26 ANAPC12 C9orf17
Fields
>>Cell cycle;>>Oocyte meiosis;>>Ubiquitin mediated proteolysis;>>Progesterone-mediated oocyte maturation;>>Human T-cell leukemia virus 1 infection
Human protein sequence Database
Q8NHZ8
Mouse protein sequence database
Q99JP4
Rat protein sequence database
Q6YDN7
Cellular localization
Nucleus .
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