Immunogen
Synthesized peptide derived from human NH2L1 AA range: 33-83
Specificity
This antibody detects endogenous levels of NH2L1 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Originally named because of its sequence similarity to the Saccharomyces cerevisiae NHP2 (non-histone protein 2), this protein appears to be a highly conserved nuclear protein that is a component of the [U4/U6.U5] tri-snRNP. It binds to the 5' stem-loop of U4 snRNA. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],
Function
function:Binds to the 5'-stem-loop of U4 snRNA and may play a role in the late stage of spliceosome assembly. The protein undergoes a conformational change upon RNA-binding.,similarity:Belongs to the ribosomal protein L7Ae family.,subcellular location:Concentrated in the dense fibrillar component of the nucleolus.,subunit:Interacts with RAD17.,tissue specificity:Ubiquitous.,
Fields
>>Ribosome biogenesis in eukaryotes;>>Spliceosome
Human protein sequence Database
P55769
Mouse protein sequence database
Q9D0T1
Rat protein sequence database
P55770
Cellular localization
Nucleus . Nucleus, nucleolus . Concentrated in the dense fibrillar component of the nucleolus. .
Tissue expression
Ubiquitous.
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