Immunogen
Synthesized peptide derived from human NOSTN AA range: 309-359
Specificity
This antibody detects endogenous levels of NOSTN at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Nitric oxide (NO) is a potent mediator in biologic processes such as neurotransmission, inflammatory response, and vascular homeostasis. NOSTRIN binds the enzyme responsible for NO production, endothelial NO synthase (ENOS; MIM 163729), and triggers the translocation of ENOS from the plasma membrane to vesicle-like subcellular structures, thereby attenuating ENOS-dependent NO production.[supplied by OMIM, Apr 2004],
Function
domain:The FCH domain is necessary for membrane targeting.,domain:The SH3 domain mediates interaction with NOS3, DNM2 and WASL.,function:Multivalent adapter protein which may decrease NOS3 activity by inducing its translocation away from the plasma membrane.,similarity:Contains 1 FCH domain.,similarity:Contains 1 SH3 domain.,subcellular location:Enriched in selected actin structures.,subunit:Homotrimer. Interacts with DAB2 (By similarity). Interacts with NOS3, DNM2, WASL and CAV1.,tissue specificity:Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).,
Human protein sequence Database
Q8IVI9
Mouse protein sequence database
Q6WKZ7
Rat protein sequence database
Q5I0D6
Cellular localization
[Isoform 1]: Cell membrane ; Peripheral membrane protein ; Cytoplasmic side . Cytoplasmic vesicle . Cytoplasm, cytoskeleton . Enriched in selected actin structures (PubMed:16234328, PubMed:16376344).; [Isoform 3]: Nucleus .
Tissue expression
Expressed at highest levels in heart, kidney, placenta and lung, and at lowest levels in brain, thymus and spleen. Present in vascular endothelial cells and placenta. Over-expressed in placenta from women with pre-eclampsia (at protein level).
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