Immunogen
Synthesized peptide derived from human RIP AA range: 117-167
Specificity
This antibody detects endogenous levels of RIP at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Function
function:Mediates the import of RPA complex into the nucleus, possibly via some interaction with importin beta. Isoform 2 is sumoylated and mediates the localization of RPA complex into the PML body of the nucleus, thereby participating in RPA function in DNA metabolism.,PTM:Isoform 2 is sumoylated. Sumoylation is required for localization in the nuclear PML body and transport of RPA complex in PML body. Upon UV irradiation and during S phase, it is desumoylated, releasing RPA complex that is translocated to sites of DNA damage. Sumoylation takes place at different Lys residues.,similarity:Contains 1 RIP-type zinc finger.,subcellular location:Only nuclear, localizes to PML body.,subunit:Interacts with the RPA1 subunit of RPA complex.,tissue specificity:Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis
Human protein sequence Database
Q86UA6
Mouse protein sequence database
Q9CWY9
Rat protein sequence database
Q4G2Y1
Cellular localization
[Isoform 1]: Cytoplasm. Nucleus.; [Isoform 2]: Nucleus, PML body.
Tissue expression
Widely expressed. Expressed in pancreas, kidney, muscle, liver, lung, placenta, brain, heart, leukocytes, colon, intestine, ovary, testis, prostate, thymus and spleen.
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