Immunogen
Synthesized peptide derived from human HERC3 AA range: 985-1035
Specificity
This antibody detects endogenous levels of HERC3 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012],
Function
function:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.,pathway:Protein modification; protein ubiquitination.,PTM:Ubiquitinated; which promotes degradation by the proteasome.,similarity:Contains 1 HECT (E6AP-type E3 ubiquitin-protein ligase) domain.,similarity:Contains 7 RCC1 repeats.,subcellular location:Also found in vesicular-like structures.,
Fields
>>Ubiquitin mediated proteolysis
Human protein sequence Database
Q15034
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm. Cytoplasmic vesicle. Also found in vesicular-like structures.
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