Immunogen
Synthesized peptide derived from human ATG12 AA range: 80-130
Specificity
This antibody detects endogenous levels of ATG12 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
Autophagy is a process of bulk protein degradation in which cytoplasmic components, including organelles, are enclosed in double-membrane structures called autophagosomes and delivered to lysosomes or vacuoles for degradation. ATG12 is the human homolog of a yeast protein involved in autophagy (Mizushima et al., 1998 [PubMed 9852036]).[supplied by OMIM, Mar 2008],
Function
function:Required for autophagy.,similarity:Belongs to the ATG12 family.,subunit:Conjugated to ATG5.,tissue specificity:Ubiquitous.,
Gene Name
ATG12 APG12 APG12L
Fields
>>FoxO signaling pathway;>>Autophagy - other;>>Autophagy - animal;>>NOD-like receptor signaling pathway;>>RIG-I-like receptor signaling pathway;>>Shigellosis
Human protein sequence Database
O94817
Mouse protein sequence database
Q9CQY1
Rat protein sequence database
Q2TBJ5
Cellular localization
Cytoplasm . Preautophagosomal structure membrane ; Peripheral membrane protein . TECPR1 recruits the ATG12-ATG5 conjugate to the autolysosomal membrane.
Tissue expression
Ubiquitous.
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