Immunogen
Synthesized peptide derived from human HMGB3 AA range: 123-173
Specificity
This antibody detects endogenous levels of HMGB3 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of a family of proteins containing one or more high mobility group DNA-binding motifs. The encoded protein plays an important role in maintaining stem cell populations, and may be aberrantly expressed in tumor cells. A mutation in this gene was associated with microphthalmia, syndromic 13. There are numerous pseudogenes of this gene on multiple chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014],
Function
function:Binds preferentially single-stranded DNA and unwinds double stranded DNA.,similarity:Belongs to the HMGB family.,similarity:Contains 2 HMG box DNA-binding domains.,tissue specificity:Expressed predominantly in placenta.,
Gene Name
HMGB3 HMG2A HMG4
Human protein sequence Database
O15347
Mouse protein sequence database
O54879
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Cytoplasm .
Tissue expression
Expressed predominantly in placenta.
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