Immunogen
Synthesized peptide derived from human N4BP2 AA range: 256-306
Specificity
This antibody detects endogenous levels of N4BP2 at Human
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a protein containing a polynucleotide kinase domain (PNK) near the N-terminal region, and a Small MutS Related (Smr) domain near the C-terminal region. The encoded protein can bind to both B-cell leukemia/lymphoma 3 (BCL-3) and neural precursor cell expressed, developmentally downregulated 4, (Nedd4) proteins. This protein binds and hydrolyzes ATP, may function as a 5'-polynucleotide kinase, and has the capacity to be a ubiquitylation substrate. This protein may play a role in transcription-coupled DNA repair or genetic recombination. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016],
Function
domain:The Smr domain has nicking endonuclease activity, but no significant double strand cleavage or exonuclease activity.,function:Has 5'-polynucleotide kinase and nicking endonuclease activity. May play a role in DNA repair or recombination.,PTM:Ubiquitinated; this targets the protein for degradation by the proteasome.,similarity:Contains 1 CUE domain.,similarity:Contains 1 Smr domain.,subunit:Binds NEDD4 (By similarity). Binds BCL3 and CREBBP.,
Gene Name
N4BP2 B3BP KIAA1413
Human protein sequence Database
Q86UW6
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cytoplasm .
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