Immunogen
Synthesized peptide derived from human FBX18 AA range: 799-849
Specificity
This antibody detects endogenous levels of FBX18 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. It contains an F-box motif and seven conserved helicase motifs, and has both DNA-dependent ATPase and DNA unwinding activities. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008],
Function
function:DNA-dependent ATPase. Unwinds double-stranded DNA in a 3' to 5' direction.,function:Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation.,similarity:Belongs to the helicase family. UvrD subfamily.,similarity:Contains 1 F-box domain.,subunit:Part of a SCF E3 ubiquitin ligase complex consisting of SKP1, CUL1, RBX1 and FBXO18. Interacts with SKP1.,
Gene Name
FBXO18 FBH1 FBX18
Human protein sequence Database
Q8NFZ0
Mouse protein sequence database
Q8K2I9
Rat protein sequence database
Cellular localization
Nucleus . Chromosome . Accumulates at sites of DNA damage or replication stress (PubMed:19736316, PubMed:23677613). PCNA is required for localization to DNA damage sites (PubMed:23677613). Localizes to the nucleoplasm in absence of DNA damage (PubMed:23677613). .
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