Immunogen
Synthesized peptide derived from human NAL12 AA range: 456-506
Specificity
This antibody detects endogenous levels of NAL12 at Human/Mouse
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1:500-2000;IHC-p 1:50-300; ELISA 2000-20000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013],
Function
disease:Defects in NLRP12 are the cause of familial cold autoinflammatory syndrome type 2 (FCAS2) [MIM:611762]. FCAS are rare autosomal dominant systemic inflammatory diseases characterized by episodes of rash, arthralgia, fever and conjunctivitis after generalized exposure to cold.,function:May mediate activation of CASP1 via ASC and promote activation of NF-kappa-B via IKK.,induction:By nitric oxide and DMSO in HL60 cells, an acute myeloid leukemia cell line.,similarity:Belongs to the NLRP family.,similarity:Contains 1 DAPIN domain.,similarity:Contains 1 NACHT domain.,similarity:Contains 8 LRR (leucine-rich) repeats.,subunit:Binds to ASC with its DAPIN domain.,tissue specificity:Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.,
Gene Name
NLRP12 NALP12 PYPAF7 RNO
Fields
>>NOD-like receptor signaling pathway
Human protein sequence Database
P59046
Mouse protein sequence database
E9Q5R7
Rat protein sequence database
Cellular localization
Cytoplasm .
Tissue expression
Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
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