Immunogen
Synthesized peptide derived from human CXXC4 AA range: 15-65
Specificity
This antibody detects endogenous levels of CXXC4 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
This gene encodes a CXXC-type zinc finger domain-containing protein that functions as an antagonist of the canonical wingless/integrated signaling pathway. The encoded protein negatively regulates wingless/integrated signaling through interaction with the post synaptic density protein/ Drosophila disc large tumor suppressor/ zonula occludens-1 protein domain of Dishevelled, a scaffolding protein required for the stabilization of the transcriptional co-activator beta-catenin. In addition, the CXXC domain of this protein has been shown to bind unmethylated CpG dinucleotides, localize to promoters and CpG islands, and interact with the catalytic domain of methylcytosine dioxygenase ten-eleven-translocation 2, an iron and alpha-ketoglutarate-dependent dioxygenase that modifies the methylation status of DNA. In humans, a mutation in this gene has been associated with development of malignant renal cell carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015],
Function
function:Acts as a negative regulator of the Wnt signaling pathway via its interaction with DVL1.,similarity:Contains 1 CXXC-type zinc finger.,subunit:Interacts with the PDZ domain of DVL1.,
Fields
>>Wnt signaling pathway
Human protein sequence Database
Q9H2H0
Mouse protein sequence database
Q6NXI8
Rat protein sequence database
Q9EQC9
Cellular localization
Cytoplasm .
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