Immunogen
Synthesized peptide derived from human TRI11 AA range: 128-178
Specificity
This antibody detects endogenous levels of TRI11 at Human/Mouse/Rat
Source
Polyclonal, Rabbit,IgG
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB 1：500-2000
Purification process (Immunogen)
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Background
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008],
Function
domain:The coiled-coil domain and the B30.2 domain are both necessary for interaction with humanin.,function:May have E3 ubiquitin ligase activity. May contribute to the regulation of the intracellular level of humanin or humanin-containing proteins through the proteasomal degradation pathway.,similarity:Belongs to the TRIM/RBCC family.,similarity:Contains 1 B box-type zinc finger.,similarity:Contains 1 B30.2/SPRY domain.,similarity:Contains 1 RING-type zinc finger.,subunit:Binds cytoplasmic tail of integrin alpha-1. Interacts with the humanin peptide.,tissue specificity:Ubiquitous.,
Human protein sequence Database
Q96F44
Mouse protein sequence database
Q99PQ2
Rat protein sequence database
B1H278
Cellular localization
Cytoplasm. Nucleus.
Tissue expression
Ubiquitous.
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