Molecular weight (DA)
51kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HUCE1. AA range:271-320
Specificity
Cerebral 1 Polyclonal Antibody detects endogenous levels of Cerebral 1 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
WB: 1/500 - 1/2000. IHC: 1/100 - 1/300. ELISA: 1/20000.. IF 1:50-200
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
RRP8 (Ribosomal RNA Processing 8, Methyltransferase, Homolog (Yeast) is a Protein Coding gene. Diseases associated with RRP8 include bowen-conradi syndrome and lymphatic system cancer. Among its related pathways are Gene Expression and Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3. GO annotations related to this gene include poly(A) RNA binding and methylated histone binding. ssential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at Lys-9 (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
Function
rRNA processing, RNA processing, rRNA metabolic process, ribonucleoprotein complex biogenesis, ncRNA processing,ncRNA metabolic process, ribosome biogenesis,
Protein name
Ribosomal RNA-processing protein 8
Other name
RRP8; KIAA0409; NML; hucep-1; Ribosomal RNA-processing protein 8; Cerebral protein 1; Nucleomethylin
Human protein sequence Database
O43159
Mouse protein sequence database
Q9DB85
Rat protein sequence database
Cellular localization
Nucleus, nucleolus . Localizes at rDNA locus.
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