Molecular weight (DA)
50kD
Immunogen
Synthesized peptide derived from SR-3D . at AA range: 10-90
Specificity
SR-3D Polyclonal Antibody detects endogenous levels of SR-3D protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The protein encoded this gene belongs to the ligand-gated ion channel receptor superfamily. This gene encodes subunit D of the type 3 receptor for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a mitogen and a hormone. This hormone has been linked to neuropsychiatric disorders, including anxiety, depression, and migraine. Serotonin receptors causes fast and depolarizing responses in neurons following activation. The genes encoding subunits C, D and E of this type 3 receptor form a cluster on chromosome 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2009],
Function
function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. This receptor is a ligand-gated ion channel, which when activated causes fast, depolarizing responses. It is a cation-specific, but otherwise relatively nonselective, ion channel.,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subcellular location:Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.,subunit:Forms a pentaheteromeric complex with HTR3A, homomeric complex being not functional.,tissue specificity:Expressed in liver, as well as fetal and adult colon and kidney.,
Protein name
5-hydroxytryptamine receptor 3D
Other name
HTR3D; 5-hydroxytryptamine receptor 3D; 5-HT3-D; 5-HT3D; Serotonin receptor 3D
Fields
>>Serotonergic synapse;>>Taste transduction
Human protein sequence Database
Q70Z44
Mouse protein sequence database
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein . Presumably retained within the endoplasmic reticulum unless complexed with HTR3A.
Tissue expression
Expressed in liver, as well as fetal and adult colon and kidney.
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