Molecular weight (DA)
36kD
Immunogen
The antiserum was produced against synthesized peptide derived from human HTR5A. AA range:15-64
Specificity
SR-5A Polyclonal Antibody detects endogenous levels of SR-5A protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) has been implicated in a wide range of psychiatric conditions and also has vasoconstrictive and vasodilatory effects. The gene described in this record is a member of 5-hydroxytryptamine (serotonin) receptor family and encodes a multi-pass membrane protein that functions as a receptor for 5-hydroxytryptamine and couples to G-proteins. This protein has been shown to function in part through the regulation of intracellular Ca2+ mobilization. [provided by RefSeq, Jul 2008],
Function
function:This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.,similarity:Belongs to the G-protein coupled receptor 1 family.,
Protein name
5-hydroxytryptamine receptor 5A
Other name
HTR5A; 5-hydroxytryptamine receptor 5A; 5-HT-5; 5-HT-5A; 5-HT5A; Serotonin receptor 5A
Fields
>>Calcium signaling pathway;>>Neuroactive ligand-receptor interaction;>>Serotonergic synapse
Human protein sequence Database
P47898
Mouse protein sequence database
P30966
Rat protein sequence database
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Brain,Cerebellum,
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