Molecular weight (DA)
81kD
Immunogen
Synthesized peptide derived from NTT4 . at AA range: 240-320
Specificity
NTT4 Polyclonal Antibody detects endogenous levels of NTT4 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The SLC6 family of proteins, which includes SLC6A17, acts as specific transporters for neurotransmitters, amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Mar 2008],
Function
function:Not yet known, orphan transporter.,similarity:Belongs to the sodium:neurotransmitter symporter (SNF) family.,
Protein name
Sodium-dependent neutral amino acid transporter SLC6A17
Other name
SLC6A17; NTT4; Sodium-dependent neutral amino acid transporter SLC6A17; Sodium-dependent neurotransmitter transporter NTT4; Solute carrier family 6 member 17
Human protein sequence Database
Q9H1V8
Mouse protein sequence database
Q8BJI1
Rat protein sequence database
P31662
Cellular localization
Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynapse . Cell junction, synapse, presynapse . Localizes at synaptic junctions - at both pre- and post-synaptic sites - particularly in excitatory glutamatergic terminals. .
Tissue expression
Hippocampus,
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