Molecular weight (DA)
47kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GHRHR. AA range:351-400
Specificity
GHRH-R Polyclonal Antibody detects endogenous levels of GHRH-R protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
This gene encodes a receptor for growth hormone-releasing hormone. Binding of this hormone to the receptor leads to synthesis and release of growth hormone. Mutations in this gene have been associated with isolated growth hormone deficiency (IGHD), also known as Dwarfism of Sindh, a disorder characterized by short stature. [provided by RefSeq, Jun 2010],
Function
disease:Defects in GHRHR are a cause of isolated growth hormone deficiency type IB (IGHD IB) [MIM:262400]; also known as pituitary dwarfism I. IGHD IB is an autosomal recessive deficiency of GH which cause short stature.,function:Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.,similarity:Belongs to the G-protein coupled receptor 2 family.,tissue specificity:Pituitary gland.,
Protein name
Growth hormone-releasing hormone receptor
Other name
GHRHR; Growth hormone-releasing hormone receptor; GHRH receptor; Growth hormone-releasing factor receptor; GRF receptor; GRFR
Fields
>>Neuroactive ligand-receptor interaction;>>Growth hormone synthesis, secretion and action
Human protein sequence Database
Q02643
Mouse protein sequence database
P32082
Rat protein sequence database
Q02644
Cellular localization
Cell membrane; Multi-pass membrane protein.
Tissue expression
Pituitary gland.
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