Molecular weight (DA)
96kD
Immunogen
The antiserum was produced against synthesized peptide derived from human GPR133. AA range:461-510
Specificity
GPR133 Polyclonal Antibody detects endogenous levels of GPR133 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Dilution rate
Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Purification process (Immunogen)
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Background
The adhesion G-protein-coupled receptors (GPCRs), including GPR133, are membrane-bound proteins with long N termini containing multiple domains. GPCRs, or GPRs, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins (summary by Bjarnadottir et al., 2004 [PubMed 15203201]).[supplied by OMIM, Nov 2010],
Function
function:Orphan receptor.,similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily.,similarity:Contains 1 GPS domain.,
Protein name
Probable G-protein coupled receptor 133
Other name
GPR133; PGR25; Probable G-protein coupled receptor 133; G-protein coupled receptor PGR25
Human protein sequence Database
Q6QNK2
Mouse protein sequence database
Q80T32
Rat protein sequence database
Cellular localization
Cell membrane ; Multi-pass membrane protein .
Tissue expression
Up-regulated in CD133(+) cell population of glioblastoma.
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